A bomber remotely has detonated an explosives-laden car outside the home of a former Pakistani minister, killing at least eight people and wounding 30.
The car was parked outside the house of Naseer Mengal, a former minister of petroleum and natural resources, according to police officials in the city of Quetta.
Several militants exchanged fire with private security guards after the blast.
Paramilitary forces cordoned off the area and were searching for the assailants.
The explosion shattered windows and knocked down electricity lines. Live video from local TV channels showed clouds of smoke rising from burning cars at the site of the bombing.
Emergency services and police officials said they expected the casualty figure to rise.
Baluchistan is Pakistan’s biggest but poorest province, where Baluch separatists militants are fighting a protracted insurgency to demand more autonomy and control over the natural resources of their impoverished region.
Much of the violence in the past has been blamed on separatist militants.
Pro-Taliban militants are also active in the province which shares borders with Afghanistan and Iran.
Pakistan, a key US ally in its war on terror, has seen a wave of violence in past years, most of it in the north-west where troops are battling militants.